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Armstrong 21 July It cannot undo many of the changes produced by naturally occurring puberty , which may necessitate surgery and other treatments see below. Two pellets should be inserted for every 25 mg of parenteral testosterone needed weekly. The extent of these changes and the time interval for maximum change varies across patients and may take up to 18 to 24 months to occur. Experimental and Clinical Endocrinology. Progestogens, in conjunction with the hormone prolactin , are involved in the maturation of the lobules , acini , and areola during pregnancy: In addition, diabetes is a significant risk factor for cardiovascular disease and may have an important role in raising the risk of cardiovascular morbidity in trans women on estrogen, as this comorbidity has been found to be prevalent among the transgender population
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